Non-cardiac Chest Pain (NCCP) - American College of Gastroenterology (2024)

  1. Patients may be treated as if the NCCP was due to acid reflux:
  • Acid blocking drugs called proton pump inhibitors (PPIs) can be used to treat NCCP, since the most common cause of NCCP is acid reflux.
  • PPIs should be taken 30 minutes before breakfast for 2 weeks. About 80% of patients with NCCP due to GERD feel better after trying PPIs.
  • If the patient improves, the treatment can be continued for several months.
  • For patients who don’t improve after taking PPIs, GERD may not be their source of NCCP:
    • It is important to know that other treatments are available. These drugs act on the nerves that travel through the esophagus to reduce pain.
    • These drugs can also be used to treat depression, anxiety or panic attacks. The doses used for NCCP are much lower.
  • Treating stress:
    • If patients do not feel better with the above treatments, or they suffer from depression, anxiety, or panic attacks, they should seek further help. This may include seeing a psychiatrist.
    • Talk therapy, hypnosis, and coping skills training can improve NCCP.
    • New studies are being done to find new treatments for NCCP.
  • Author(s) and Publication Date(s)

    Sami R. Achem, MD, FACG, Mayo College of Medicine, Mayo Clinic, Jacksonville, FL – Published February 2009. Updated July 2013.

    Jennifer X. Cai, Brigham and Women's Hospital, Boston, MA – Updated June 2022.

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    Non-cardiac Chest Pain (NCCP) - American College of Gastroenterology (2024)
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