Semaglutide (Subcutaneous Route) Precautions - Mayo Clinic (2024)

Precautions

Drug information provided by: Merative, Micromedex®

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Tell your doctor if you are pregnant or planning to become pregnant. Do not use this medicine for at least 2 months before you plan to become pregnant.

It is very important to carefully follow any instructions from your health care team about:

  • Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team.
  • Other medicines—Do not take other medicines during the time you are using semaglutide unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.
  • Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, diabetic patients may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur during pregnancy in patients with diabetes.
  • Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times.

In case of emergency—There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says that you have diabetes and a list of all of your medicines.

This medicine may increase the risk of having thyroid tumors. Tell your doctor right away if you have a lump or swelling in your neck or throat, trouble swallowing or breathing, or if your voice gets hoarse.

Pancreatitis (swelling of the pancreas) may occur while you are using this medicine. Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Check with your doctor right away if you have gaseous stomach pain, indigestion, recurrent fever, severe nausea or vomiting, stomach fullness, or yellow eyes or skin. These may be symptoms of gallbladder problems (eg, cholelithiasis, cholecystitis).

This medicine may cause diabetic retinopathy. Check with your doctor if you have blurred vision or any other changes in vision.

This medicine does not cause hypoglycemia (low blood sugar). However, low blood sugar can occur when you use semaglutide with other medicines, including insulin or sulfonylureas, that can lower blood sugar. Low blood sugar also can occur if you delay or miss a meal or snack, exercise more than usual, drink alcohol, or cannot eat because of nausea or vomiting.

  • Symptoms of low blood sugar include anxiety, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool, pale skin, difficulty with thinking, drowsiness, excessive hunger, fast heartbeat, headache (continuing), nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness.
  • If symptoms of low blood sugar occur, eat glucose tablets or gel, corn syrup, honey, or sugar cubes, or drink fruit juice, non-diet soft drink, or sugar dissolved in water to relieve the symptoms. Also, check your blood for low blood sugar. Glucagon is used in emergency situations when severe symptoms including seizures or unconsciousness occur. Have a glucagon kit available, along with a syringe and needle, and know how to use it. Members of your family should also know how to use it.

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Check with your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat while you are using this medicine.

This medicine may cause acute kidney injury. Check with your doctor right away if you have a bloody urine, decreased urine output, muscle twitching, nausea, rapid weight gain, seizures, stupor, swelling of the face, ankles, or hands, or unusual tiredness or weakness.

This medicine may increase your heart rate while you are at rest. Check with your doctor right away if you have fast or pounding heart beat.

Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your antidiabetic medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual.

  • Symptoms of high blood sugar include blurred vision, drowsiness, dry mouth, flushed, dry skin, fruit-like breath odor, increased urination (frequency and amount), ketones in the urine, loss of appetite, stomachache, nausea or vomiting, tiredness, trouble breathing (rapid and deep), unconsciousness, or unusual thirst.
  • If symptoms of high blood sugar occur, check your blood sugar level and then call your doctor for instructions.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Also tell your doctor if you have sudden or strong feelings, including feeling nervous, angry, restless, violent, or scared. If you or your caregiver notice any of these side effects, tell your doctor right away.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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  • Proper Use
  • Side Effects

Portions of this document last updated: April 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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Semaglutide (Subcutaneous Route) Precautions - Mayo Clinic (2024)

FAQs

Semaglutide (Subcutaneous Route) Precautions - Mayo Clinic? ›

This medicine may increase the risk of having thyroid tumors. Tell your doctor right away if you have a lump or swelling in your neck or throat, trouble swallowing or breathing, or if your voice gets hoarse. Pancreatitis (swelling of the pancreas) may occur while you are using this medicine.

What is the half life of semaglutide subcutaneous? ›

Semaglutide is a newer GLP-1 agonist, administered once-weekly. It conveys a similarity to human GLP-1 of 94%, having two amino-acid substitutions (Lau et al., 2015) and has a half-life of 1 week.

What is the dark side of semaglutide? ›

Pancreatitis (swelling of the pancreas) may occur while you are using this medicine. Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

What happens if semaglutide gets warm? ›

In fact, studies show that semaglutide injections will be viable even if exposed to temperatures as high as 104°F (40°C) for up to three days. Even if your vials are warm when they arrive, they can still be safely used as long as they are promptly transferred to refrigerated conditions of 36-46°F (2-8°C) once received.

What happens if semaglutide is injected into muscle? ›

When injecting semaglutide, it is vital to ensure that the medication is not injected into muscles or veins. Injecting any medication directly into a muscle can cause increased absorption and intense metabolization of the drug, leading to an overdose or side effects.

How to inject subcutaneously? ›

Hold the syringe at a 90-degree angle to your skin so it's standing straight out, right above the place where you'll give the injection. Quickly jab the needle all the way into the pinched-up skin, then push the plunger all the way in so the medicine empties out of the syringe.

How to flush semaglutide out of your system? ›

There's no specific antidote for a semaglutide overdose. The drug has a half-life of about a week, meaning it takes one week to clear half of it from your body.

How long does semaglutide stay in your bloodstream? ›

At its typical dose, semaglutide has a half-life of 7 days and is administered once weekly for 4–5 weeks to achieve steady state, or consistent levels in the body. After stopping semaglutide, it can take that same amount of time for it to be fully eliminated from your system.

How long does it take for semaglutide to suppress appetite? ›

On average, short-term effects of Semaglutide can begin as early as the first 1 to 4 weeks of use. During these initial weeks of use, you may notice a reduced appetite. An increase in feelings of fullness after eating will also be noticeable. Additionally, you will begin to see early signs of weight loss.

Is semaglutide hard on the liver? ›

Thus, liver injury due to semaglutide must be rare, if it occurs at all. Likelihood score: E (unlikely cause of clinically apparent liver injury).

What can you not do on semaglutide? ›

Foods to avoid when using semaglutide
  • fried foods or foods high in saturated/trans fat.
  • spicy foods.
  • fatty protein cuts.
  • baked goods, candy, and ice cream.
  • beverages with added sugar, such as regular soda, juice, and energy drinks.
Apr 4, 2024

Why do I feel so bad on semaglutide? ›

However, semaglutide also affects the gastrointestinal tract by increasing the amount of glucagon. This has two effects on the digestive tract. First, it slows down the movement of food through your gut, which can lead to nausea, vomiting, and diarrhea.

What happens if I don't refrigerate semaglutide? ›

(Ozempic is prescribed to help manage blood sugar levels in people with type 2 diabetes.) With refrigeration, unopened Ozempic will last until the expiration date printed on the carton. Left unrefrigerated, the active ingredient (semaglutide) may go bad before its expiration date.

Does semaglutide change your smell? ›

Some people have reported a change in the way their urine smells after taking Wegovy or other semaglutide products such as Ozempic, often describing it as now having a strong unusual odor.

Why is semaglutide compounded with B12? ›

Compounding Semaglutide injections and cyanocobalamin provide additional ingredients that increase Semaglutide's effectiveness and reduce side effects. Specifically, combining Semaglutide with vitamin B12 creates a potent appetite suppressant that boosts metabolism, energy levels, and chronic weight management.

Where is the best place to inject semaglutide for weight loss? ›

The medication should be injected into areas that have sufficient subcutaneous fat between the skin and muscle. Injecting into these fatty layers allows for comfortable injections and proper absorption of the drug. Some of the best areas for semaglutide injections are the thighs and the abdomen around the belly button.

What happens if semaglutide is not refrigerated? ›

With refrigeration, unopened Ozempic will last until the expiration date printed on the carton. Left unrefrigerated, the active ingredient (semaglutide) may go bad before its expiration date.

Is semaglutide subcutaneous or intramuscular? ›

Semaglutide injection comes as a solution (liquid) in a prefilled dosing pen to inject subcutaneously (under the skin). It is usually injected once a week without regard to meals.

Should you eat before injecting semaglutide? ›

Never share medicine pens with others under any circ*mstances. It is not safe for one pen to be used for more than one person. Sharing needles or pens can result in transmission of infection. Use this medicine on the same day each week, at any time of the day, with or without meals.

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